![]() ![]() All- trans-retinoic acid, SR11237 (a synthetic retinoid X receptor-specific ligand), and meta-carboxy-TTNPB (an inactive synthetic retinold) did not have these properties. We found that 13-tisrethaoic acid induced, in a concentration-dependent fashion, a type 1-like pattern of growth under conditions for which a type 2 pattern was expected. ![]() ![]() In the present study, we searched for compounds that might influence type 1 or type 2 patterns of growth. ![]() As in our previous studies of human and sheep follicles ( Dev Biol 165:469, 1994), we found in this system that transection level dictates the pattern of (follicle growth in vitro: follicles transected below the sebaceous gland show a type I growth pattern (the shaft grows out with an adherent sheath), while nontransected follides show a type 2 growth pattern (a naked shaft grows out lacking a sheath). Because equine mane follicles are large and noncurved, enabling easy dissection are readily accessible from a single defined source and possess a long anagen growth phase, we initiated a study of them in culture. A major challenge to the study of hair follicle growth is an appropriate assay system. ![]()
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